The rear axle from an 88 and up trooper should fit pretty close and be discs. You might have some creativity to get the e-brake cables to hook up, but I'd guess the rest would be fairly simple. The Isuzu 12 bolt axle is really quite strong, up there with a D44 on the break-o-meter, and there are locker/LSD options for it.
The only other item I can think of to complicate things would be the driveline attachment. You might have to have some custom driveline work done. Most come with 4.56 gears, but 4.77 came with the "wide tire" option, and there are other options out there. Check out the FAQ over at
http://www.independent4x.com for info on axles used in Isuzus through the years.