LUVdiesel--
I have been using synthetics in my two Isuzu P'ups for about 10 years and
don't really know if I have had any trouble related to lubrication.
I say 'don't know' because the Isuzu trannys like to wear out some of their bearings at about 75k to 150k miles with or without synthetics. The big input shaft bearing seems to be the one most likely to fail although I have had others go too. I have rebuilt 3 of these and one of my friends rebuilt his.
Still, I think the synthetics have the edge over regular engine oil. And, since the synthetics tend to have an improved viscosity index, they remain thinner at cold temperatures. This makes the tranny easier to shift when cold.
I have used either 5- 50 or 10- 40 weight in the trannys.
I have also been using a synthetic gear lube in the differentials, 75-80 weight, with never any differential trouble.
I find it strange that Isuzu's engines last for several hundred thousand miles without too much trouble but the trannys have a much shorter life.
Paul
Here is a photo just for entertainment:
