Zack & All--
Well, the 3.42 ratio is terrific on the highway and we have lots of them. It is less good on steep grades and when towing.
In my dreams I would have this gear ratio and a gear splitting transmission so that I would have the 'perfect gear' for any occasion.
Or, I could just install a high torque V8 and leave it in top gear all the time

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But, until my dream comes true or I go mad with a V8 I think I would just compromise by sticking with the stock 3.73 gears. I have driven the truck both ways and either is pretty good for my use. One needs to keep the revs under control no matter which gears one has.
Zack, are you sure you have a 3.73, as my calculation indicates that one would have about 2400 rpm in 4th at 50 mph with a 3.73 rear end and 195x14 tires. And you have indicated 2700 rpm. Maybe you already have a 3.90? What is your tire size? I am assuming that 4th is straight thru in your box.
And yes, your rpm change from 4th to 5th calculates out to a 30% change, a large change for a small engine. The Isuzu trannys change only 14 % between 4th & 5th.
I am embedding a chart I made up to show the relationship between engine speed, gear ratio and road speed. This chart is made up for 3.42 gears and 195x14 tires. It also shows the difference btween a diesel transmission and a gas transmission. I am thinking of using a gear set from a gasser in a diesel case to get the closer ratios. I think later model gas trannys had still closer ratios.
Paul